1898 - Oscar Raab revealed the property of acrydine dye to kill paramecia upon irradiation with light.
1900 - H. Tappeiner introduced the term «photodynamic action».
1903 - H. Tappeiner et Jesionek (Munich) were the first to treat the face basalioma.
1905 - The same authors treated 6 skin cancer patients. In 4 of them the remission period was 1 year and more.
1908 - V. Hausmann described the action of blood-derived tetrapyrrole photosensitizer hematoporphyrin IX (HP) on cells and animals.
1913 - F. Meyer-Betz made an intravenous self-injection of HP to investigate its biological action.
1924 - A. Policard found out the fluorescence of malignant tumor in the red part of spectrum, and explained it by the accumulation of endogenous porphyrine.
1942 - Auler and Banzer reported about HP affinity to tumors, that was confirmed in 1948 by F. H. J. Figge: the fluorescence of tumor-associated HP upon Woods lamp light.
1961 - Lipson et.al performed its i/v injection of «hematoporphyrin derivative» and revealed its accumulation in tumor by fluorescence after violet light excitation.
1966 - Lipson et.al performed breast cancer treatment and introduced the term PDT.
1978 - Dougherty group (USA) applied HpD PDT in the treatment of cancer patients with cancer of breast, head and neck skin, bronchus, esophagus, stomach, and female genitals.
1970-1980 s. - Experimental study of porphyrins, chlorins, phtalocyanines. Chlorin dyes (aspartyl-chlorin ć6) were first mentioned as PDT agents in 1986. (J.Bommer, Z.Sveida and B.Burnham).
