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Photodynamic therapy

Main requirements to photosensitizers (PS)

  • Low toxicity at therapeutic doses in light and darkness.
  • Highly tumor-targeting accumulation and fast elimination from the skin and epithelium.
  • Absorption peak in the low-loss transmission window of biological tissues (the far-red and near-infrared regions).
  • Optimum ratio of the fluorescence/interconversion quantum yield (the first parameter determines the photosensitizer diagnostic capabilities, it plays a key role in monitoring the photosensitizer accumulation in tissues and its clearance from them; the last parameter determines the photosensitizer ability to generate singlet oxygen).
  • High quantum yield of singlet oxygen production in vivo.
  • Available obtaining or synthesis, homogeneous composition.
  • High solubility in water, injection solutions and blood substitutes.
  • Storage and application light stability.

Photosensitizers

Preparation Compound l (nm)
Photohem (Russia)
Photofrin (USA)
Photosan (Germany)
HPD (China)
Hematoporphyrine derivative 630
Photosens (Russia) Sulfonated phtalocyanines 675
Photoditazine
Radachlorin (Russia)
Chlorins 662
Bacteriochlorin (Germany) Pheophorbite 780

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