PDT application

At the initial stages of cancer, PDT is applied for skin cancer (extended, superficial, multiple, with inconvenient locations on face and auricle) for cancer of lung, esophagus, bladder(superficial, multiple nodular), genitals to archive complete recovery (radical program). PDT is used in combined and complex treatment along with surgery and radiotherapy for relapses of skin cancer, cancer of low lip, tongue, intracutaneous metastases, breast cancer relapses on the chest, for intracutaneous melanoma metastases, usually in combination with polychemotherapy. For obstructive tumors of trachea, large bronchus, esophagus and cardial stomach, PDT is used to recanalize the organs. PDT provides less complications and longer remission period in comparison with laser photodestruction.

Indications to PDT

Skin Cancer

• Relapsing and residual tumors that are resistant to traditional therapeutic techniques.
• Multiple (primarily multiple) tumors.
• Extended tumors (more that 10 cm, infiltration depth up to 1 cm).
• Tumors with inconvenient locations (periorbital region, nasolabial fold, nose wings, auricle and external acoustic duct, etc.).
• Patients’ refusal to the treatment with routine techniques (surgery and radiotherapy).
• Histological forms: basal cell carcinoma, squamous cell carcinoma, and metatypical carcinoma.

Oropharyngeal Region

• Squamous cell carcinoma Т1-2N0M0 (up to 3 cm, infiltration depth up to 1 cm).
• High risk of complications in elderly patients and patients with associated diseases after radiotherapy and surgery.
• Relapsing and residual tumors.
• Patients’ refusal to the treatment with routine techniques.

Lung Cancer

• Central cancer Т1-2N0M0 affecting the trachea, major, intermediate, and lobe bronchi (PDT is not contraindicated even in the case of atelectasis, exophytic and endophytic cancer [even with circular lesions]).
• High risk of complications after surgery and radiotherapy in elderly patients and patients with associated diseases.
• Patients’ refusal to the treatment with traditional methods.

Esophagus Cancer

• Primary cancer Т1N0M0, when surgical and/or combined treatments are contraindicated.
• Early cancer relapses after radiotherapy.
• Patients’ refusal to the treatment with routine therapeutic techniques.
• Palliative PDT performed to recanalize obturating tumors.

Stomach Cancer

• Primary cancer Т1N0M0 of any histological structure, whith mucous and submucous growth.
• Early relapses in anastomosis.
• Palliative PDT of stenosing cancer of the cardial portion of the stomach, performed to recanalize the organ.
• Patients’ refusal to the treatment with traditional techniques.

Urinary Bladder Cancer

• Superficial cancer of the urinary bladder (primary or relapsing cancer).
• Exophytic cancer Т1N0M0 of the urinary bladder, affecting its bottom and sidewalls (PDT can be applied to multiple lesions, irrespective of the previous treatment).
• Relapsing tumors, inefficiency of traditional treatment, and indications to cystectomy.

Breast Cancer

• Padget cancer Т1-2N0M0.
• Relapsing breast cancer after surgical treatment.
• Intracutaneous metastases after surgical and combined treatments (PDT is not contraindicated in the case of the simultaneous administration of radiotherapy and chemotherapy).
• Primary breast cancer Т1N0M0 (the nodular form) when the patients refuse to the surgical treatment and/or have serious associated diseases.

Rectum Cancer

• Rectum cancer Т1N0M0 when surgical treatment is contraindicated.
• Palliative PDT, which is performed to recanalize organs obturated by tumors.